The Relationship Of Corneal Topographic Parameters With Corneal And Lens Densitometers In Patients With Keratoconus

Aim: The aim of this study was to investigate the relationship between corneal-lens densitometry and the corneal topographic parameters in keratoconus patients.Material and Methods: The database of the Pentacam (R) HR device between 2017 and 2019 was analyzed retrospectively. A total of 85 eyes of 85 keratoconus patients and 55 right eyes of 55 healthy control subjects were included in the study. The corneal density was measured manually in the full-thickness cornea with a diameter of 2 mm in the corneal apex. The lens density was measured manually in the pupillary area with a diameter of 2 mm throughout the whole central lens thickness.Results: Maximum corneal density was significantly higher in keratoconus patients [15.96 +/- 2.52 (10.2-20.0)] compared with healthy control subjects [14.22 +/- 2.41 (9.0-19.3)] (p<0.001). The mean lens density [7.55 +/- 0.56 (7.0-9.1)] was lower in keratoconus patients compared with healthy control subjects [7.93 +/- 1.07 (7.0-11.3); p=0.007)]. Additionally, the mean keratometry value and the maximum lens density value were negatively correlated with each other (p=0.018).Discussion: Corneal density is increased and the lens density decreased in keratoconus patients. It was determined that the lens density decreased while the corneal density increased in keratoconus patients. These results suggest that several factors may cause corneal and lenticular alterations in these patients.