Synthesis And Ecotoxicological Studies Of Ionic Compounds Based On Tolperisone, Diphenhydramine And Trimecaine

Ionic compounds have been of global interest since stepping into a mature field of research. The aim of this study was to synthesize novel and known ionic compounds via the N-alkylation process and fully characterize them by elemental analysis and infrared (IR) and nuclear magnetic resonance (NMR) spectroscopy. Investigation of the influence of the alkyl chain length and the charge of the cation on the ecotoxicity of 11 new and known ionic compounds based on tolperisone, diphenhydramine and trimecaine was investigated with the use of luminescence inhibition assay. To give information about the ecotoxicity of these new ionic compounds, the acute toxicity dataset of each compound was determined using Aliivibrio fischeri bacteria as a biomodel. According to the obtained results, the studied compounds could be considered non-harmful to Aliivibrio fischeri. A quantitative structure-activity relationship (QSAR) study was carried out with the aim of modelling the observed behaviour and providing a prediction basis for ecotoxicity towards Aliivibrio fischeri.