Similar Molecular Subtypes of Lung Injury Patterns in Interstital Lung Disease, Stem Cell and Lung Transplantation

Obliteration of bronchioles of the lung (BO) as well as collagenous obliteration of alveoli with elastosis summarized as alveolar fibroelastosis (AFE) are injury patterns of the lung observed in chronic lung allograft dysfunction (CLAD), following lung transplantation (LuTx) as well as after hematopoetic stem cell transplantation (HSCT), combined radio-chemotherapy and in subforms of interstitial lung disease. Regardless of the clinical background both injury patterns are associated with a high mortality.