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Targeting DNA Topoisomerases or Checkpoint Kinases Results in an Overload of Chaperone Systems, Triggering Aggregation of a Metastable Subproteome

Wouter Huiting,Suzanne L. Dekker,Joris C. J. van der Lienden,Rafaella Mergener,Maiara K. Musskopf,Gabriel Furtado,Emma Gerrits, David Coit,Mehrnoosh Oghbaie,Luciano H. Di Stefano,Hein Schepers,Maria A. W. H. Van Waarde-Verhagen,Suzanne Couzijn,Lara Barazzuol,John LaCava,Harm H. Kampinga,Steven Bergink

eLife（2022）

引用 7|浏览21
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关键词
genotoxic stress,protein homeostasis,protein aggregation,DNA damage response,chaperone,Human
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