USF2 knockdown downregulates THBS1 to inhibit the TGF-β signaling pathway and reduce pyroptosis in sepsis-induced acute kidney injury

Jian Sun,Xiaoli Ge,Yang Wang,Lei Niu,Lujia Tang,Shuming Pan

Pharmacological Research（2022）

引用 23|浏览16

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摘要

USF2 activated the TGF-β/NLRP3/caspase-1 pathway by up-regulating THBS1 via binding to THBS1, to promote pyroptosis and aggravate sepsis-induced AKI.ga1

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关键词

Sepsis-induced acute kidney injury,Pyroptosis,USF2,THBS1,TGF-β/Smad3 pathway,Oxidative stress

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