De-Intensified (DI) IMPT vs. IMRT(Chemo) for HPV-Associated Oropharynx Cancer (HPV-OPC): Initial Quality of Life (QOL) Results From a Prospective, Multi-Institutional Trial

DI IMPT(chemo) and IMRT(chemo) resulted in favorable patient-reported QOL/symptoms with most patients reporting return to baseline QOL/symptom scores by 3 mo with some exceptions. DI IMPT(chemo) resulted in very low rate of feeding tube use and less swallowing/eating-related symptoms compared with IMRT(chemo) using independently validated instruments. Additional data and long-term follow-up will be needed to validate these findings and confirm the long-term safety/efficacy of DI RT(chemo).