SARS-CoV-2 in Conjunctiva and Tears and Ocular Symptoms of Patients with COVID-19

Teresa Rodríguez-Ares,David Lamas-Francis,Mercedes Treviño,Daniel Navarro,María Cea, María Jesús López-Valladares,Laura Martínez,Francisco Gude,Rosario Touriño

Vision（2021）

University of Santiago de Compostela | Department of Ophthalmology | Department of Microbiology | Faculty of Medicine

Cited 9|Views12

Abstract

This study investigates the presence of SARS-CoV-2 in conjunctival secretions and tears and evaluates ocular symptoms in a group of patients with COVID-19. We included 56 hospitalized patients with COVID-19 in this cross-sectional cohort study. Conjunctival secretions and tears were collected using flocked swabs and Schirmer strips for SARS-CoV-2 reverse-transcriptase polymerase chain reaction (RT-PCR). Assessment of ocular surface manifestations included an OSDI (Ocular Surface Disease Index) questionnaire. Patients had been admitted to hospital for an average of 2.4 days (range 0–7) and had shown general symptoms for an average of 7.1 days (range 1–20) prior to ocular testing. Four (7.1%) of 56 conjunctival swabs and four (4%) of 112 Schirmer strips were positive for SARS-CoV-2. The mean E-gene cycle threshold values (Ct values) were 31.2 (SD 5.0) in conjunctival swabs and 32.9 (SD 2.7) in left eye Schirmer strips. Overall, 17 (30%) patients presented ocular symptoms. No association was found between positive ocular samples and ocular symptoms. This study shows that SARS-CoV-2 can be detected on the conjunctiva and tears of patients with COVID-19. Contact with the ocular surface may transmit the virus and preventive measures should be taken in this direction.

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Key words

COVID-19,coronavirus,SARS-CoV-2,tears,conjunctiva,ocular surface

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