Physiologically-Based Pharmacokinetic Modeling to Investigate the Effect of Maturation on Buprenorphine Pharmacokinetics in Newborns with Neonatal Opioid Withdrawal Syndrome

Matthijs W. van Hoogdalem,Trevor N. Johnson,Brooks T. McPhail,Suyog Kamatkar,Scott L. Wexelblatt,Laura P. Ward,Uwe Christians,Henry T. Akinbi,Alexander A. Vinks,Tomoyuki Mizuno

CLINICAL PHARMACOLOGY & THERAPEUTICS（2022）

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PBPK modeling,biliary clearance,buprenorphine,neonatal abstinence syndrome,neonatal opioid withdrawal syndrome,pediatrics,pharmacogenetics,precision dosing

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