Discovery of Covalent Bruton's Tyrosine Kinase Inhibitors with Decreased CYP2C8 Inhibitory Activity.

Hui Qiu,Zahid Ali, Julian Bowlan,Richard Caldwell,Anna Gardberg,Nina Glaser,Andreas Goutopoulos,Jared Head,Theresa Johnson,Christine Maurer,Katrin Georgi,Roland Grenningloh,Zhizhou Fang,Federica Morandi,Felix Rohdich,Ralf Schmidt,Ariele Viacava Follis,Brian Sherer

ChemMedChem（2021）

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covalent BTK inhibitor,acrylamide,cyanamide

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