Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis.
ACS Medicinal Chemistry Letters(2021)
关键词
Farnesoid X receptor (FXR),Nonalcoholic steatohepatitis (NASH),Nuclear hormone receptor (NHR),FGF15,CYP7a1,spirocycle,azaspiro[3.5]nonene
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