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Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis

Joseph Carpenter,Gang Wu,Ying Wang,Erica M. Cook,Tao Wang,Doree Sitkoff, Karen A. Rossi,Kathy Mosure,Xiaoliang Zhuo,Gary G. Cao,Milinda Ziegler,Anthony Azzara, Jack Krupinski,Matthew G. Soars,Bruce Alan Ellsworth,Dean A. Wacker

ACS medicinal chemistry letters（2021）

Cited 3|Views30
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Key words
Farnesoid X receptor (FXR),Nonalcoholic steatohepatitis (NASH),Nuclear hormone receptor (NHR),FGF15,CYP7a1,spirocycle,azaspiro[3.5]nonene
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