Species-Specific Differences in C-5 Sterol Desaturase Function Influence the Outcome of Azole Antifungal Exposure.
Antimicrobial agents and chemotherapy(2021)
摘要
The azole antifungals inhibit sterol 14α-demethylase (S14DM), leading to depletion of cellular ergosterol and the synthesis of an aberrant sterol diol that disrupts membrane function. In Candida albicans , sterol diol production is catalyzed by the C-5 sterol desaturase enzyme encoded by ERG3 .
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关键词
C-5 desaturase,Candida,ERG3,antifungal,azole,ergosterol,resistance,tolerance
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