Non-Thyroidal Illness Syndrome-Associated Multiorgan Dysfunction after Surgical Repair of Type A Aortic Dissection

Objective: The purpose of this cohort study was to investigate the relationship between non-thyroidal illness syndrome (NTIS) and severe multi organ dysfunction, measured by Sequential Organ Failure Assessment score >11, after surgical repair of type A aortic dissection (TAAD). Setting: An observational study. Participants: The present study included 310 patients with TAAD surgically repaired between January 2019 and December 2020 in Beijing Anzhen Hospital. Interventions: Patients after surgical repair after TAAD. Measurements and Main Results: Among a total of 310 patients with TAAD undergoing surgical repair included in this study, 132 (42.6%) experienced surgery-associated NTIS. Severe multiorgan dysfunction was experienced more often in patients with NTIS (27.3% v 11.2%, p < 0.0001). Multivariate analysis demonstrated NTIS was associated closely with an increased risk of severe multiorgan dysfunction (odds ratio [OR] = 2.54, 95% CI = 1.39-4.64 p = 0.002), which predicted an in-hospital death rate of 95%. Non-thyroidal illness syndrome also was related with in-hospital major adverse cardiovascular and cerebral events (OR = 2.12, 95% CI = 1.30-3.46 p = 0.003), acute kidney injury (OR = 3.17, 95% CI = 1.17-8.47 p = 0.023), and postoperative pulmonary complications (OR = 2.32, 95% CI = 1.34-4.03 p = 0.003). However, hepatic inadequacy was comparable in the NTIS and control groups. Conclusions: Non-thyroidal illness syndrome was associated closely with multiorgan dysfunction after surgical repair of TAAD, which may be correlated further with an increased incidence of in-hospital mortality and complications. (C) 2021 Elsevier Inc. All rights reserved.