Detection of Granzyme B in CD3-positive Cells Infiltrated in Lesional Skin of a Dog with Erythema Multiforme Associated with Zonisamide.
Journal of veterinary medical science(2021)
摘要
In human erythema multiforme (EM), cytotoxic T lymphocytes (CTLs) play an essential role in the pathogenesis. In canine EM, immunohistochemical staining with anti-CD8 antibody using frozen sections has shown the involvement of CTLs; however, CTL infiltration has never been quantitatively analyzed. We herein quantitatively analyzed CTL infiltration by immunohistochemical staining with granzyme B and CD3 antibodies using paraffin sections of a dog with EM associated with zonisamide. The present results indicated approximately 70% of cells at the border between the epidermis and dermis consisted of CTLs. Detection of granzyme B and CD3 using paraffin sections employed in this study can be a clinically applicable method for detecting CTLs.
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关键词
CD3,cytotoxicT lymphocytes,dog,erythema multiform,granzyme B
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