Aiolos: a molecular guardian of type 2 innate immune cell residency and response

Recent findings by Felton et al. and Qiu et al. unveil the importance of the transcription factor Aiolos for tissue-resident eosinophils and group 2 innate lymphoid cells (ILC2s). The authors find that Aiolos regulates the transcriptomic profile and chromatin landscape, both of which are essential for eosinophil and ILC2 localisation in tissues, as well as their function. These studies place Aiolos as a molecular guardian that regulates tissue-resident type 2 innate cells.