Antitumor compound, synthesis method and applications thereof

The invention belongs to the field of medicinal chemistry, and particularly relates to an antitumor compound, a synthesis method and applications thereof, wherein the compound has a structure represented by a general formula I or a general formula II, and shows good inhibitory activity on proteasome regulatory kinase DYRK2, so that antitumor activity can be achieved by inhibiting proteasome. The invention also relates to a synthesis method of the compound, wherein the method adopts a chemical total synthesis route, and the convergent synthesis route can be applied to chemical synthesis of compounds with similar structures and related derivatives, and develops a wide development space for novel antitumor drugs.