“Resurrected” human-source urate oxidase with high uricolytic activity and stability

Nan Jiang, Chunqin Xu, Linhan Zhang,Jianhua Chen

Enzyme and Microbial Technology（2021）

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摘要

•Human-source urate oxidase with high activity and stability was constructed.•Maintaining 93.75 % homology with deduced human urate oxidase.•Amino acid sites related to the enzyme activity were distinguished.

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关键词

Gout,Urate oxidase,Pseudogene,Site-directed mutagenesis

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