Neisseria Meningitidis Serogroup Z Meningitis in a Child with Complement C8 Deficiency and Potential Cross Protection of the MenB-4C Vaccine.

Bryan van den Broek,Jordy P. M. Coolen,Marien I. de Jonge,Ronald de Groot,Stefanie S. V. Henriet,Jeroen D. Langereis,Michiel van der Flier

The Pediatric infectious disease journal/The pediatric infectious disease journal（2021）

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摘要

Complement deficient patients are susceptible to rare meningococcal serogroups. A 6-year-old girl presented with serogroup Z meningitis. This led to identification of a C8 deficiency. The MenB-4C vaccine induced cross-reactive antibodies to serogroup Z and increased in vitro opsonophagocytic killing and may thus protect complement deficient patients.

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关键词

vaccine,MenB-4C,Neisseria meningitidis,immune compromised,complement deficiency

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