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Stabilization of the SARS-CoV-2 Spike Receptor-Binding Domain Using Deep Mutational Scanning and Structure-Based Design

Daniel Ellis,Natalie Brunette,Katharine H. D. Crawford,Alexandra C. Walls,Minh N. Pham,Chengbo Chen,Karla-Luise Herpoldt,Brooke Fiala,Michael Murphy,Deleah Pettie,John C. Kraft,Keara D. Malone,Mary Jane Navarro,Cassandra Ogohara,Elizabeth Kepl,Rashmi Ravichandran,Claire Sydeman,Maggie Ahlrichs,Max Johnson,Alyssa Blackstone,Lauren Carter,Tyler N. Starr,Allison J. Greaney,Kelly K. Lee,David Veesler,Jesse D. Bloom,Neil P. King

Frontiers in immunology（2021）

Cited 23|Views23
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Key words
SARS-CoV-2,vaccine,nanoparticle,antigen stabilization,receptor-binding domain,computational protein design,deep mutational scanning
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