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Development of a Safe and Scalable Process for the Production of a High-Purity Thiocarbamate-Based Ionizable Lipid As an Excipient in Mrna-Encapsulating Lipid Nanoparticles

Kumar Rajappan,Steven P. Tanis,Scott Roberts,Priya Karmali, Padmanabh Chivukula, Jin Zhuang, Mingxing Xin, Manman Zheng, Ian Edmonds

Organic Process Research & Development(2021)

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cationic lipid,lipid nanoparticle,acyl imidazole,acyl imidazolium salt,mutagen,methyl trifluoromethanesulfonate,lipophilic amine salt
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