STATE OF THE HUMAN INNATE IMMUNITY CELL COMPONENT DURING 120-DAY ISOLATION IN A PRESSURIZED MODULE

Innate immunity was investigated in six 28 to 44 y.o. volunteers for 120-d isolation in controlled environment. Peripheral blood samples gathered during isolation were analyzed to determine monocytes and granulocytes expressing intracellular (TLR3, TLR8, TLR9) and surface (TLR1, TLR2, TLR4, TLR5, TLR6) TLRs, and lymphocytes-natural killers (CD3-CD16+CD56+). The system of pattern-recognition cell receptors displayed a heterogenic reaction with primary activation throughout the period in isolation. The observed changes represent evidently the processes of establishing a dynamic balance of immunity with extreme factors of the life in isolation and confinement, including the reactions to endogenous and exogenous stimuli.