Low‐dose Hydrocortisone in Patients with COVID‐19 and Severe Hypoxia: the COVID STEROID Randomised, Placebo‐controlled Trial Marie Warrer Munch , Tine Sylvest Meyhoff , Marie Helleberg , Maj-Brit Norregaard Kjaer , Anders Granholm , Carl Johan Steensen Hjortso , Thomas Steen Jensen , Morten Hylander Moller , Peter Buhl Hjortrup , Mik Wetterslev , Gitte Kingo Vesterlund , Lene Russell , Vibeke Lind Jorgensen , Klaus Tjelle Kristiansen , Thomas Benfield , Charlotte Suppli Ulrik , Anne Sofie Andreasen , Morten Heiberg Bestle , Lone Musaeus Poulsen , Thomas Hildebrandt , Lene Surland Knudsen , Anders Moller , Christoffer Grant Solling , Anne Craveiro Brochner , Bodil Steen Rasmussen , Henrik Nielsen , Steffen Christensen , Thomas Strom , Maria Cronhjort , Rebecka Rubenson Wahlin , Stephan M. Jakob , Luca Cioccari , Balasubramanian Venkatesh , Naomi Hammond , Vivekanand Jha , Sheila Nainan Myatra , Marie Qvist Jensen , Jens Wolfgang Leistner , Vibe Sommer Mikkelsen , Jens S. Svenningsen , Signe Bjorn Laursen , Emma Victoria Hatley , Camilla Meno Kristensen , Ali Al-Alak , Esben Clapp , Trine Bak Jonassen , Caroline Lokke Bjerregaard , Niels Christian Haubjerg Osterby , Mette Mindedahl Jespersen , Dalia Abou-Kassem , Mathilde Languille Lassen , Reem Zaabalawi , Mohammed Mahmoud Daoud , Suhayb Abdi , Nick Meier , Kirstine Cour , Cecilie Bauer Derby , Birka Ravnholt Damlund , Jens Laigaard , Lene Lund Andersen , Johan Mikkelsen , Jeppe Lundholm Stadarfeld Jensen , Anders Horby Rasmussen , Emil Arnerlov , Mathilde Lykke , Mikkel Zacharias Bystrup Holst-Hansen , Boris Wied Tostesen , Janne Schwab , Emilie Kabel Madsen , Christian Gluud , Theis Lange , Anders Perner Acta anaesthesiologica Scandinavica/Acta anaesthesiologica scandinavica（2021）
摘要
In the early phase of the pandemic, some guidelines recommended the use of corticosteroids for critically ill patients with COVID‐19, whereas others recommended against the use despite lack of firm evidence of either benefit or harm. In the COVID STEROID trial, we aimed to assess the effects of low‐dose hydrocortisone on patient‐centred outcomes in adults with COVID‐19 and severe hypoxia.
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corticosteroids, COVID-19, hydrocortisone, placebo-controlled trial, randomised clinical trial, SARS-CoV-2
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