Oxytocin Receptor Induces Mammary Tumorigenesis Through Prolactin/p-Stat5 Pathway

Dan Li,Mingjun San,Jing Zhang,Anlan Yang,Wanhua Xie,Yang Chen,Xiaodan Lu,Yuntao Zhang,Mingyue Zhao,Xuechao Feng,Yaowu Zheng

Cell Death & Disease（2021）SCI 1区SCI 2区

Transgenic Research Center | The Precise Medicine Center

Cited 12|Views27

Abstract

Oxytocin receptor (OXTR) is involved in social behaviors, thermoregulation, and milk ejection, yet little is known about its role in breast cancer. To investigate the role of OXTR in mammary gland development and tumorigenesis, a transgenic mouse model of OXTR overexpression (++Oxtr) was used. Overexpression of OXTR-induced progressive mammary hyperplasia, unexpected milk production, and tumorigenesis in females. OXTR-induced mammary tumors showed ERBB2 upregulation and mixed histological subtypes with predomination of papillary and medullary carcinomas. OXTR overexpression led to an activation of prolactin (PRL)/p-STAT5 pathway and created a microenvironment that promotes mammary-specific tumorigenesis. PRL inhibitor bromocriptine (Br) could mitigate OXTR-driven mammary tumor growth. The study demonstrates Oxtr is an oncogene and a potential drug target for HER2-type breast cancer.

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Key words

Breast cancer,Cancer models,Life Sciences,general,Biochemistry,Cell Biology,Immunology,Cell Culture,Antibodies

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