Warm Distension Fluid Reduces Pain Severity in Office Hysteroscopy: a Randomized Controlled Trial

BACKGROUND:Abnormal uterine bleeding (AUB) affects approximately 14% to 25% of women of reproductive age. The most common use of office hysteroscopy is to evaluate pathologies related to AUB and reproductive health, but office hysteroscopy can also be used for the diagnosis and treatment of other intrauterine pathologies.OBJECTIVE:Investigate the effects of the temperature of the distension fluid on pain severity in patients undergoing diagnostic office hysteroscopy due to AUB.DESIGN:Randomized controlled clinical trial.SETTING:Tertiary care center in Turkey.PATIENTS AND METHODS:One hundred perimenopausal patients with AUB were randomly allocated according to the temperature of the distension fluid used in office hysteroscopy (37°C or 25°C). Pain intensity was assessed using a visual analog scale (VAS). Six VAS measurements were compared over the course of the hysteroscopy: pre-treatment (VAS-1), at vaginal entry (VAS-2), at the cervical ostium transition (VAS-3), while in the cavity (VAS-4), at the end of the procedure (VAS-5), and 30 minutes after the end of the procedure (VAS-6).MAIN OUTCOME MEASURE:VAS SAMPLE SIZE: Fifty in each group enrolled, one drop out.RESULTS:The VAS-3, VAS-4, and VAS-5 scores were significantly lower for patients in the warm fluid group than in the room temperature group (P<.05), whereas the VAS-1, VAS-2, and VAS-6 scores were similar in both groups.CONCLUSION:The application of warm distension fluid in office hysteroscopy reduces pain severity compared with the application of an unheated fluid.LIMITATIONS:The main limitations of the study were that a subgroup analysis could not be performed due to an insufficient number of cases, and we were unable to evaluate vasovagal symptoms.CONFLICT OF INTEREST:None.