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Links Between Toxoplasma gondii IgG Seropositivity and Serointensity and Measures of Geriatric Frailty, Depression and Cognitive Impairment

Teodor Postolache,Blanca Laffon,Hira Mohyuddin,Eduardo Pasaro,Diego Marcos-Perez,Niel Constantine,Aline Dagdag,John W. Stiller,Heidi Ortmeyer,Iqra Mohyuddin,Christopher Marano,Christopher A. Lowry,Lisa A. Brenner,Vanessa Valdiglesias

BIOLOGICAL PSYCHIATRY（2021）

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Abstract
“Frailty” is characterized by decreased physiological adaptive reserve and increased morbidity and mortality. Immune dysregulation is considered a potential contributor to frailty. Chronic infection with Toxoplasma gondii (Tg) is linked with low grade immune activation, cognitive impairment and depression. We thus hypothesized positive associations between frailty, cognitive deficits, and depression with Tg IgG titers and seropositivity in older adults.
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Frailty,Late Life Depression,Cognitive Impairment,Toxoplasma Gondii,Anti-Toxoplasma Gondii Antibodies
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