Design, Synthesis and Antibacterial Evaluation of Novel C-11, C-9 or C-2′-substituted 3-O-descladinosyl-3-ketoclarithromycin Derivatives

Bingfang Bai,Fangchao Bi,Yinhui Qin,Yuetai Teng,Shutao Ma

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（2021）

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摘要

•Novel 3-O-descladinosyl-3-keto-clarithromycin derivatives were synthesized and evaluated.•Some of them showed effective activity against resistant strains.•Compound 9b exhibited prominent antibacterial activity.

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关键词

Antibacterial activity,Bacterial resistance,Synthesis,3-O-descladinosyl-3-keto-clarithromycin derivatives

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