Pd(Ii)/(S)-T-Bupyox-Catalyzed Asymmetric Addition Of Arylboronic Acids To N-Sulfonyl-Arylaldimines

The asymmetric version of Pd(II)/bipyridine-catalyzed nucleophilic addition of arylboronic acids to N-sulfonyl arylaldimines was developed, and excellent asymmetric induction was achieved by the use of chiral pyridinooxazoline ligand (S)-t-BuPyOx. Moisture and oxygen-insensitive catalysis was realized under mild conditions, and 9 out of 16 examples gave 92-99% ee. (C) 2021 Elsevier Ltd. All rights reserved.