P84.14 Identification of Mechanisms of Resistance to ALK Inhibitors. Next-Generation Sequencing-Based Liquid Biopsy Profiling.

E. Sanchez-Herrero,R. Serna-Blasco, V. Ivanchuk,R. Garcia Campelo,M. Domine Gomez,J. M. Sanchez,B. Massuti,N. Reguart,C. Camps,S. Sanz-Moreno, S. Farinas, E. Jantus-Lewintre, M. Arnal, D. Fernandez-Orth,V. Gonzalez-Rumayor,V. Calvo,M. Provencio, A. Romero

Journal of thoracic oncology（2021）

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摘要

Despite impressive and durable responses, patients treated with ALK inhibitors (ALK-Is) ultimately progress. We investigated potential resistance mechanisms in a series of ALK-positive non-small cell lung cancer (NSCLC) patients progressing on different types of ALK-Is.

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关键词

NSCLC,ALK,NGS

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