HIV integrase inhibitors that inhibit strand transfer interact with RAG1 and hamper its activities

International Immunopharmacology（2021）

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摘要

•Recombination activating gene 1 (RAG1) and HIV integrase share functional similarity through the shared DDE motif.•HIV integrase inhibitor, Elvitegravir, can affect RAG functions in vitro and in vivo.•Dolutegravir and Raltegravir have minimal effect, compared to Elvitegravir.

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关键词

AIDS,RAG complex,Human immunodeficiency Virus,V(D)J recombination,Immunodeficiency,Retrovirus

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