A Robust Control Solution for Glycaemia Regulation of Type-1 Diabetes Mellitus

The paper addresses the development of an artificial pancreas for the treatment of Type 1 Diabetes Mellitus, and more precisely the design of a control law for insulin delivery. As opposed to current existing solutions, the proposed approach is patient-independent, so it tackles the variability of the patients. Robust margins and worst-case performance are also established by means of the H∞/µ-analysis theory. The proposed solution is evaluated through the high-fidelity UVA/Padova simulator accepted by the US Food and Drug Administration as a substitute for pre-clinical testing of new treatment strategies.