Allosteric activation of SARS-CoV-2 RdRp by remdesivir triphosphate and other phosphorylated nucleotides.

Bing Wang,Vladimir Svetlov,Yuri I Wolf,Eugene V Koonin,Evgeny Nudler,Irina Artsimovitch

bioRxiv : the preprint server for biology（2021）

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摘要

Codon-optimization of Nsp12 triggers misfolding and activity lossSlow translation, accessory Nsp7 and Nsp8 subunits, and NTPs rescue Nsp12Non-substrate nucleotides activate RNA chain synthesis, likely via NiRAN domainCrosstalk between two Nsp12 active sites that bind the same ligands.

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