Safety, Pharmacokinetics and Pharmacodynamics of HTL0009936, a Selective Muscarinic M1‐acetylcholine Receptor Agonist: A Randomized Cross‐over Trial

Charlotte Bakker,Samantha Prins,Jan Liptrot,Ellen P. Hart,Erica S. Klaassen,Giles A. Brown,Alastair Brown,Miles Congreve,Malcolm Weir,Fiona H. Marshall,Jasper Stevens,David M. Cross,Tim Tasker,Pradeep J. Nathan,Geert Jan Groeneveld

BJCP British journal of clinical pharmacology/British journal of clinical pharmacology（2021）

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摘要
HTL0009936 is a selective M1 muscarinic receptor agonist in development for cognitive dysfunction in Alzheimer's disease. Safety, tolerability and pharmacokinetics and exploratory pharmacodynamic effects of HTL0009936 administered by continuous IV infusion at steady state were investigated in elderly subjects with below average cognitive functioning (BACF).
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关键词
Alzheimer&apos,s disease,cholinergic system,elderly,M-1 receptor,muscarinic receptors,pharmacokinetics,safety
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