Pharmacophore study using the HipHop for the screening novel potential BH3-mimetic compounds

Beclin-1 was bound to and inhibited by Bcl-2 or the Bcl-2 homolog Bcl-XL, this interaction involves a Bcl-2 homology 3 (BH3) domain in Beclin-1 and the BH3 binding groove of Bcl-2/Bcl-XL. In order to find a new BH3-mimetic compound to disrupt the combination of Beclin-1 and Bcl-2 and promote autophagy, we used the HipHop for screening novel potential BH3-mimetic compounds. The hit compounds were s...