Supramolecular Complex of 20-Hydroxyecdysone-3-acetate with β-Cyclodextrin and Its Biological Activity

B. I. Tuleuov, B. S. Temirgaziev, A. M. Kozhanova, R. B. Seydakhmetova,K. M. Turdybekov,T. M. Seilkhanov,O. T. Seilkhanov, P. Drasar,S. M. Adekenov

RUSSIAN JOURNAL OF GENERAL CHEMISTRY（2021）

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摘要

In order to obtain new potentially bioactive substances and to investigate the effect of bulky functional groups on the formation of supramolecular complexes, 20-hydroxyecdysone triacetate has been synthesized, its spatial structure has been determined, and its complexation with β-cyclodextrin has been studied by means of NMR. The anti-inflammatory activity of the obtained water-soluble complex has been assessed.

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20-hydroxyecdysone triacetate,β-cyclodextrin,supramolecular complex,X-ray diffraction analysis,NMR spectroscopy

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