MP62-13 ADDED VALUE OF QUANTITATIVE DCE IMAGING ON MPMRI PREDICTION OF STAGE ≥PT3 PROSTATE CANCER

You have accessJournal of UrologyProstate Cancer: Staging I (MP62)1 Apr 2020MP62-13 ADDED VALUE OF QUANTITATIVE DCE IMAGING ON MPMRI PREDICTION OF STAGE ≥PT3 PROSTATE CANCER Rossano Girometti, Fabio Zattoni*, Gioacchino De Giorgi, Giannarini Gianluca, Claudio Valotto, Carlotta Zaborra, Chiara Zuiani, and Fabrizio Dal Moro Rossano GiromettiRossano Girometti More articles by this author , Fabio Zattoni*Fabio Zattoni* More articles by this author , Gioacchino De GiorgiGioacchino De Giorgi More articles by this author , Giannarini GianlucaGiannarini Gianluca More articles by this author , Claudio ValottoClaudio Valotto More articles by this author , Carlotta ZaborraCarlotta Zaborra More articles by this author , Chiara ZuianiChiara Zuiani More articles by this author , and Fabrizio Dal MoroFabrizio Dal Moro More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000937.013AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To investigate whether quantitative dynamic contrast-enhanced imaging (DCE) can improve the diagnosis of pathological stage ≥T3 (≥pT3) when staging prostate cancer (PCa) with multiparametric magnetic resonance imaging (mpMRI). METHODS: Over a two years period, we retrospectively included 63 patients with biopsy-proven PCa who underwent preoperative mpMRI on a 3.0T equipment, using a Prostate Imaging Reporting and Data System version 2 (PI- RADSv2)-compliant protocol. Two readers in consensus (3 and 10 years of experience), blinded to nal pathology, manually drawn volumetric regions of interest over PI-RADS ≥2 observations, calculating the volume transfer costant (Ktrans) and rate costant (Kep) with the Tofts extended model. Readers assessed extraprostatic disease by using a morphological 1-5 PI-RADSv2-derived score. We calculated the sensitivity and speci city for stage ≥pT3 of mpMRI alone, mpMRI+Ktrans, mpMRI+ Kep, and mpMRI+ Ktrans+ Kep. Thresholds for Ktrans/Kep and areas under the curve (AUC) were derived from receiver operating characteristic analysis. RESULTS: Final pathology found 70 cancers, showing stage ≥pT3 in 30.0% of cases. mpMRI alone showed 61.9% (95%CI 38.4-81.9) sensitivity, 89.8% (95%CI 77.8-96.6) speci city and AUC of 0.76 (95%C.I. 0.64-0.85). Cut-off values for Ktrans and Kep were 0.28 and 1.39, respectively. Sensitivity, speci city and AUC were 95.2% (95%CI 76.2-99.9), 55.1% (95%CI 40.2-69.3) and 0.75 (95%C.I. 0.634- 0.847) for mpMRI+ktrans, 95.2% (95%CI 76.2-99.9), 63.3% (95%CI 48.3-76.6) and 0.79 (95%CI 0.68 to 0.88) for mpMRI+kep, and 90.5% (95%CI 69.6-98.8), 75.5% (95%CI 61.1-86.7) and 0.83 (95%CI 0.72-0.91) for mpMRI+ktrans+kep. CONCLUSIONS: Adding Ktrans and Kep to mpMRI signi cantly increased the sensitivity for stage ≥pT3. DCE-derived parameters might be useful in the routine staging setting. Source of Funding: none © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e950-e951 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Rossano Girometti More articles by this author Fabio Zattoni* More articles by this author Gioacchino De Giorgi More articles by this author Giannarini Gianluca More articles by this author Claudio Valotto More articles by this author Carlotta Zaborra More articles by this author Chiara Zuiani More articles by this author Fabrizio Dal Moro More articles by this author Expand All Advertisement PDF downloadLoading ...