Thin-Layer-Agar-Based Direct Phenotypic Drug Susceptibility Testing on Sputum in Eswatini Rapidly Detects Mycobacterium Tuberculosis Growth and Rifampicin Resistance Otherwise Missed by WHO-Endorsed Diagnostic Tests

E. Ardizzoni, E. Ariza, D. Mulengwa, Q. Mpala,R. de la Tour,G. Maphalala,F. Varaine,B. Kerschberger, P. Graulus, A. L. Page,S. Niemann,V Dreyer,A. Van Deun,T. Decroo,L. Rigouts,B. C. de Jong

Antimicrobial agents and chemotherapy（2021）

引用 8|浏览10

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摘要

Xpert MTB/RIF rapidly detects resistance to rifampicin (RR); however, this test misses I491F-RR conferring the rpoB mutation, common in southern Africa. In addition, Xpert MTB/RIF does not distinguish between viable and dead Mycobacterium tuberculosis (MTB).

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关键词

resistance detection,TLA,Xpert MTB/RIF,tuberculosis,MDR,XDR,rpoB I491F mutant

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