An in vitro model to assess the peripheral vestibulotoxicity of aromatic solvents

V. Tallandier,M. Chalansonnet, L. Merlen, S. Boucard,A. Thomas,P. Campo,B. Pouyatos

NeuroToxicology（2021）

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摘要

•Endolymphatic K+ levels in cultured utricles reflect solvent vestibular toxicity.•O-xylene, ethylbenzene and styrene decrease K+ concentration.•No effect on K+ concentration following exposure to p-xylene, m-xylene or toluene.•Cochleotoxic solvents are not necessarily vestibulotoxic, and vice versa.

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关键词

3D,CO2,DIV,DMEM-F12,H2O2,K+,KCl,MET,NaCl,Na/K-ATPase,NKCC1,OHC,P,PBS,TBST

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