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哮喘患者嗜酸性粒细胞富集群中P物质表达上调

Yan-mei LIU,Shao-heng HE,Si-jing LU,Hui-yun ZHANG,Wen-jiao ZHENG,Jun-ling WANG,Ze-nan ZHANG,Rui-ming YANG

Acta Scientiarum Naturalium Universitatis Neimongol（2018）

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Abstract
检测哮喘患者外周血嗜酸性粒细胞富集群中SP和NK1R的表达,并探讨了其在哮喘中的可能作用.收集志愿者的静脉血液,用过敏源粗提液刺激,流式细胞术检测SP和NK1的表达.结果发现,哮喘患者Sp+嗜酸性粒细胞的比例升高了4倍,0.1μg/ml尘螨过敏源可诱导Sp+嗜酸性粒细胞的比例升高0.5倍,而NK1R+嗜酸性粒细胞的比例降低了78％.上述结果提示嗜酸性粒细胞源的SP可能在哮喘中起作用,嗜酸性粒细胞表达的NK1R可能不参与哮喘发病或作用很小.
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Key words
asthma,eosinophil,SP,NK1R
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