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利用CLIP技术研究蛋白质和RNA的相互作用

De-Jian ZHOU,Ke-Qiong YE

Chinese Bulletin of Life Sciences（2014）

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Abstract
紫外交联免疫共沉淀(CLIP)技术能揭示RNA结合蛋白质在体内的RNA结合位点.将讨论该技术的基本原理和一些新的发展,这些新发展显著地提高了技术的特异性、灵敏度和应用范围.
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Key words
UV crosslinking,protein-RNA interaction,deep sequencing
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