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    • 吉林省初治涂阳结核病患者分离株耐药谱研究

    Xiu-jun YANG,Yan-li YUAN,Wei-yu ZHANG,Bo WANG,Yun-long BAI,Yan-hua WANG

    Chinese Journal of Health Laboratory Technology（2015）

    Cited 2|Views5
    Abstract
    目的 分析吉林省初治涂阳结核病患者的耐药谱资料,为耐药结核病防治工作提供参考依据.方法 采用比例法对吉林省30个耐药监测点初治涂阳结核病患者分离株,进行异烟肼(INH)、利福平(RFP)、乙胺丁醇(EMB)、链霉素(SM)、氧氟沙星(OFX)、卡那霉素(KM)药物敏感性试验,分析结核分枝杆菌原发性耐药情况及影响因素.结果 纳入初治涂阳1 200例患者,培养阳性菌株1 175株,阳性率为97.9％;对INH、RFP、EMB、SM、OFX、KM耐药率分别为17.19％ (202/1 175)、10.47％(123/1 175)、4.34％ (51/1 175)、26.30％ (309/1 175)、5.62％ (66/1 175)、3.74％ (44/1 175);原发性耐药率为58.2％.结论 吉林省结核病患者的耐药率日益趋高,初治涂阳结核病耐药率高,应加强结核病耐药监测,有效预防和控制结核病及耐药结核病的产生和蔓延.
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    • Pretraining has recently greatly promoted the development of natural language processing (NLP)
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    • We propose a method called M6 that is able to process information of multiple modalities and perform both single-modal and cross-modal understanding and generation
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    【要点】：本研究分析了吉林省初治涂阳结核病患者的耐药谱，揭示了结核分枝杆菌的原发性耐药情况及影响因素，为耐药结核病的防治提供依据。
    

    【方法】：采用比例法对吉林省30个耐药监测点的初治涂阳结核病患者分离株进行药物敏感性试验。
    

    【实验】：研究共纳入1200例初治涂阳患者，培养阳性菌株1175株，阳性率为97.9%。对INH、RFP、EMB、SM、OFX、KM的耐药率分别为17.19%、10.47%、4.34%、26.30%、5.62%、3.74%，原发性耐药率为58.2%。结果显示吉林省结核病患者的耐药率较高，初治涂阳结核病耐药率尤为突出，提示应加强耐药监测以预防和控制结核病及耐药结核病的产生和蔓延。