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高效液相色谱法测定骨水泥中庆大霉素的释放

Yuan LI,Xiang-yu WANG,Jin-zhu MA

China Medical Device Information（2020）

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Abstract
目的:建立带药骨水泥中庆大霉素释放药量的测定方法.方法:高效液相色谱法,AgilentPoroshell 120 EC-C184μm柱,流动相:乙腈:水=95:5;流速:1.0mL/min;加样体积:20μL;柱温:25?C;检测波长265nm.结果:在0～2h有最大释放药量,且在1d、3d、5d的时间内,药物的释放量均满足带药骨水泥的药物释放要求.结论:该方法简便,准确,重现性好,可对骨水泥中庆大霉素的释放定量检测.
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