苁归益肾胶囊对糖尿病肾病模型大鼠的治疗作用
Chinese Traditional Patent Medicine(2015)
Abstract
目的 观察苁归益肾胶囊(肉苁蓉、当归、山茱萸、桂枝、泽泻、丹皮)对糖尿病肾病模型大鼠的治疗作用.方法 120只SD大鼠随机分为6组,苁归益肾胶囊高、中、低剂量组,厄贝沙坦阳性对照组,模型组和正常组,每组20只.采用STZ腹腔注射建立糖尿病肾病大鼠模型.分组造模后灌胃给药4周,检测空腹血糖、24 h尿微蛋白量、血管紧张素Ⅱ(AngⅡ)、肾组织血管紧张素Ⅱ受体1(AT1R)、血管紧张素Ⅱ受体结合蛋白(AGTRAP)、结缔组织生长因子(CTGF)的表达等指标.结果 经苁归益肾胶囊治疗4周后,大鼠24h尿蛋白、空腹血糖及AngⅡ的水平均明显低于模型组(P<0.05).结论 苁归益肾胶囊对糖尿病肾病模型大鼠有一定的治疗作用,其可能机制是抑制了大鼠的炎症反应,与抑制大鼠肾组织中AT1R、AGTRAP、CTGF的表达,降低AngⅡ的水平有关.
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Key words
Conggui Yishen Capsules,diabetic nephropathy (DN),angiotensin Ⅱ (Ang Ⅱ),angiotensin Ⅱ type 1 receptor (AT1R),angiotensin Ⅱ recepter protein (AGTRAP),connective tissue growth factor (CTGF),rat
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