杂色云芝粗多糖预防性给药对扑热息痛诱导的肝损伤小鼠的肝保护作用

Yuying BAI,Weijia GE,Enbo CAI,Hongyan ZHU,Haiying BAO,Yan ZHAO

Journal of Jilin Agricultural University（2020）

Cited 1|Views25

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Abstract

研究杂色云芝粗多糖(YZ0)对对乙酰氨基酚(APAP)诱导的小鼠急性肝损伤的保护作用及其作用机制,结果表明:与模型组相比,YZ0能显著降低小鼠血清ALT、AST、IL?1β、TNF?α、IL?6水平及肝MDA水平,显著增强肝组织中抗氧化酶(SOD、CAT)活性和GSH水平,并显现剂量依赖性.组织病理学观察显示,YZ0对肝损伤有保护作用.此外,YZ0显著抑制了APAP诱导的ERK1/2和JNK的磷酸化,从而减少了促炎细胞因子的分泌和肝细胞凋亡,揭示了YZ0对APAP诱导的小鼠肝毒性具有保护作用,其可能作用机制是减少氧化应激和炎症反应.

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