Method for modifying cells by virtue of oxygen-regulated basic fibroblast growth factor

The invention provides an oxygen-regulated basic fibroblast growth factor (bFGF) and a method for modifying cells by virtue of a gene sequence of the oxygen-regulated basic fibroblast growth factor, wherein the gene sequence of the oxygen-regulated basic fibroblast growth factor is shown as SEQ ID No.1; and the method comprises the following steps: 1, providing the gene sequence: SEQ ID No.1; 2, constructing a recombinant adeno-associated virus vector by virtue of the gene sequence SEQ ID No.1 obtained in the step 1; and 3, fusing the constructed recombinant adeno-associated virus into stem cells so as to obtain an oxygen-regulated basic fibroblast growth factor modified controllable bFGF gene expression vector; regulatable expression under special conditions is achieved; and through different expressions under normoxic and hypoxic environments, various side effects such as tissue hyperplasia and the like and tumorigenic risks caused by over-expression of the bFGF which exists in a conventional gene therapy vector for a long time can be avoided.