Application of Thermodynamic Phase Diagrams and Gibbs Free Energy of Mixing for Screening of Polymers for Their Use in Amorphous Solid Dispersion Formulation of a Non-Glass-Forming Drug
Journal of Pharmaceutical Sciences（2021）
Key words
Amorphous solid dispersions,Solubility parameters,Drug-polymer interaction parameter,Thermodynamic phase diagrams,Gibbs free energy of mixing,Melting point depression,Flory-Huggins theory,Solid-liquid equilibrium
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