Mutations In The Ras/Mapk Pathway Drive Replication Repair-Deficient Hypermutated Tumors And Confer Sensitivity To Mek Inhibition
Brittany B Campbell,Melissa A Galati,Simone C Stone, Alexandra N Riemenschneider,Melissa Edwards,Sumedha Sudhaman,Robert Siddaway,Martin Komosa,Nuno M Nunes,Liana Nobre,A Sorana Morrissy,Matthew Zatzman,Michal Zapotocky,Lazar Joksimovic,Sangeetha N Kalimuthu,David Samuel,Gary Mason,Eric Bouffet,Daniel A Morgenstern,Melyssa Aronson,Carol Durno,David Malkin,John M Maris,Michael D Taylor,Adam Shlien,Trevor J Pugh,Pamela S Ohashi,Cynthia E Hawkins,Uri Tabori CANCER DISCOVERY（2021）
关键词
repair–deficient hypermutated tumors,mutations,replication
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