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In Vitro and in Vivo Activities of TP0480066, a Novel Topoisomerase Inhibitor, Against Neisseria Gonorrhoeae.

Aiko Masuko,Iichiro Takata,Kiyoko Fujita,Hirotoshi Okumura,Fumihito Ushiyama,Hideaki Amada,Hiroyuki Sugiyama

Antimicrobial agents and chemotherapy（2021）

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Abstract
Gonorrhea is a common, sexually transmitted disease caused by Neisseria gonorrhoeae . Multidrug-resistant N. gonorrhoeae is an urgent threat, and the development of a new antimicrobial agent that functions via a new mechanism is strongly desired.
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Key words
DNA gyrase,DNA topoisomerase,MAOQ,Neisseria gonorrhoeae,TP0480066,antibiotic resistance,enzyme inhibitor
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