Non‐invasive Peripheral Focused Ultrasound Neuromodulation of the Celiac Plexus Ameliorates Symptoms in a Rat Model of Inflammatory Bowel Disease

What is the central question of this study? Does peripheral non‐invasive focused ultrasound targeted to the celiac plexus improve inflammatory bowel disease? What is the main finding and its importance? Peripheral non‐invasive focused ultrasound targeted to the celiac plexus in a rat model of ulcerative colitis improved stool consistency and reduced stool bloodiness, which coincided with a longer and healthier colon than in animals without focused ultrasound treatment. The findings suggest that this novel neuromodulatory technology could serve as a plausible therapeutic approach for improving symptoms of inflammatory bowel disease.