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Development and Optimization of Mirabegron of Solid Lipid Nanoparticles as an Oral Delivery for Overactive Bladder.

Pharmaceutical nanotechnology(2021)

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摘要
Thus, the study established that the oral bioavailability of MBN could be improved by the administration of MBN-PEG-SLN. The obtained results indicate SLNs as a potential drug delivery system for improving the bioavailability of poorly bioavailable drugs such as MBN by abating the first-pass metabolism.
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关键词
Bioavailability ,Box-Behnken design,Mirabegron,Oral delivery,PEGylation,Pre-emulsion-Ultrasonication,Solid Lipid Nanoparticles
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