Development and Optimization of Mirabegron of Solid Lipid Nanoparticles as an Oral Delivery for Overactive Bladder.
Pharmaceutical nanotechnology(2021)
摘要
Thus, the study established that the oral bioavailability of MBN could be improved by the administration of MBN-PEG-SLN. The obtained results indicate SLNs as a potential drug delivery system for improving the bioavailability of poorly bioavailable drugs such as MBN by abating the first-pass metabolism.
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关键词
Bioavailability
,Box-Behnken design,Mirabegron,Oral delivery,PEGylation,Pre-emulsion-Ultrasonication,Solid Lipid Nanoparticles
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