Genome-wide signatures of mammalian skin covering evolution
SCIENCE CHINA-LIFE SCIENCES(2021)
摘要
Animal body coverings provide protection and allow for adaptation to environmental pressures such as heat, ultraviolet radiation, water loss, and mechanical forces. Here, using a comparative genomics analysis of 39 mammal species spanning three skin covering types (hairless, scaly and spiny), we found some genes (e.g., UVRAG, POLH , and XPC ) involved in skin inflammation, skin innate immunity, and ultraviolet radiation damage repair were under selection in hairless ocean mammals (e.g., whales and manatees). These signatures might be associated with a high risk of skin diseases from pathogens and ultraviolet radiation. Moreover, the genomes from three spiny mammal species shared convergent genomic regions ( EPHB2, EPHA4 , and NIN ) and unique positively selected genes ( FZD6, INVS , and CDC42 ) involved in skin cell polarity, which might be related to the development of spines. In scaly mammals, the shared convergent genomic regions (e.g., FREM2 ) were associated with the integrity of the skin epithelium and epidermal adhesion. This study identifies potential convergent genomic features among distantly related mammals with the same skin covering type.
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关键词
comparative genomics,skin coverings,spiny mammals,hairless mammals,scaly mammals,convergent evolution
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