THE STUDY OF NUTRACEUTICAL EFFECTS OF THE WHEY ZONAR IN THE MANAGEMENT OF OBESITY EXPERIMENTALLY INDUCED IN RATS

The aim of the study was to investigate the nutraceutical functional effects of lactoserum Zonar in the management of experimentally induced obesity in Sprague - Dawley rats. The study was performed on Sprague - Dawley male rats. Animals were randomly distributed into 6 groups, 5 animals per group: Negative control group (group 1), Positive control group (group 2). Hypercaloric food and Zonar group (group 3), Standard food and Zonar group (group 4), Obesity 1 Group (group 5), Obesity 2 Group (group 6), in the first 7 weeks, groups 5 and 6 received a diet based on hyperlipidic food, and in the last 4 weeks groups underwent changes in their diet, thus group 5 was passed on a standard diet and lactoserum Zonar, and group 6 remained on the hyperlipidic and lactoserum Zonar diet. The animals were subjected weekly to anthropometric measurements by calculating the body mass index (BMI) and the obesity index (IO). Group 2 gained significantly more body weight compared to all the other groups, thus the BMI and IO were significantly increased. It was observed that rats supplemented with Zonar for 10 and 4 consecutive weeks showed a significant decrease in serum triglyceride level compared to group 2. The oxidative stress parameters TOS and MDA were significantly higher in the group 2 than in groups on Zonar diet. The curent study showed that supplementing the diet with Zonar can reduce the increase in body weight, triglyceride and cholesterol, in rats supplemented with both, high fat diet or standard diet. It was also observed that oxidative stress levels were reduced in groups supplemented with Zonar for a longer period of time.